Crofelemer

A proprietary gastro-intestinal compound in clinical development for four distinct product indications

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Total Voting Rights and Share Capital


In conformity with the Transparency Directive, Napo Pharmaceuticals, Inc. ("Napo") is required to notify the market of the following:

Napo has issued 507,614 common shares during this month and therefore Napo's current issued share capital (exclusive of shares held in treasury) now consists of 54,206,383 common shares with a nominal value of USD $.0001 each, with voting rights.

Napo Pharmaceuticals, Inc. holds 125,614 common shares in Treasury.

Therefore, the total number of voting rights in Napo (exclusive of shares held in treasury) is 54,206,383.

The above figure of 54,206,383 common shares may be used by shareholders as the denominator for the calculations by which they will determine if they are required to notify their interest in, or a change to their interest in, Napo under the Financial Service Authority's Disclosure and Transparency Rules.

Name of contact and telephone number for inquiries:

Charles Thompson
Napo Pharmaceuticals, Inc.
Company Secretary
650-616-1903

Napo Pharmaceuticals, Inc
Tel: 650-616-1900
Fax: 650-873-8367
250 East Grand Avenue, Suite 90
South San Francisco, CA 94080
USA
Delaware corporation number 3457397