Crofelemer

A proprietary gastro-intestinal compound in clinical development for four distinct product indications

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BLOCK LISTING SIX MONTHLY RETURN

 

Information provided on this form must be typed or printed electronically and provided to an ris.

 

Date: __14 Feb_____2008

 

Name of applicant:

Napo Pharmaceuticals, Inc

Name of scheme:

Blocklisting covers:

2006 Equity Incentive Plan

2001 Equity Incentive Plan

Period of return:

From:

9 June 2007

To:

14 February 2008

Balance of unallotted securities under scheme(s) from previous return:

3,119,198 common shares:

646,324 in 2006 Equity Incentive Plan

2,472,874 in 2001 Equity Incentive Plan

Plus: The amount by which the block scheme(s) has been increased since the date of the last return (if any increase has been applied for):

0

Less: Number of securities issued/allotted under scheme(s) during period (see LR3.5.7G):

20,000 in 2001 Equity Incentive Plan

Equals: Balance under scheme(s) not yet issued/allotted at end of period:

3,099,198 common shares:

646,324 in 2006 Equity Incentive Plan

2,452,874 in 2001 Equity Incentive Plan

 

Name of contact:

Charles Thompson, Chief Financial Officer

Telephone number of contact:

(001) + 650 616 1903