Napo Pharmaceuticals

news

Proposed Board Changes

South San Francisco, California, April 20, 2007 - Napo Pharmaceuticals, Inc., (LSE: NAPL), The Company acknowledges the announcement made yesterday by Lisa Conte, the Company's Chief Executive Officer. A Board meeting has been called for this weekend, the earliest practicable opportunity for the full Board to convene. An update will be provided as and when appropriate.

For more information please contact:

Napo Pharmaceuticals, Inc.
Lisa Conte, Chief Executive Officer
(001) + 650 616 1902

Charles Thompson, Chief Financial Officer
(001) + 650 616 1903

Buchanan Communications
020 7466 5000
Tim Anderson, Mary-Jane Johnson

Nomura Code Securities Limited
020 7776 1205
Clare Terlouw

About Napo Pharmaceuticals, Inc.

Napo Pharmaceuticals, Inc. is focused on developing and commercializing proprietary pharmaceuticals for the global marketplace, in collaboration with local partners, in order to address major global unmet medical needs in developed and developing countries. Napo is currently developing crofelemer, which is in various stages of clinical development for four distinct product indications, including one product in Phase III, two in Phase II and one in Phase I clinical trials. Napo's four indications include AIDS diarrhea, Irritable Bowel Syndrome (IBS), acute infectious diarrhea (traveler's diarrhea and cholera) and pediatric diarrhea. The Company has been granted FDA fast-track status for the AIDS and IBS products and has generated extensive safety data on more than 1500 patients across all indications. Napo's partners include Trine Pharmaceuticals Inc., Glenmark Pharmaceuticals of Mumbai, India and the AsiaPharm Group Ltd., headquartered in Singapore and Shanghai. Napo's clinical stage product for diabetes and metabolic syndrome, NP-500 is a candidate for Phase 2 clinical development. Napo also has a medicinal product library of over 2,300 plants, which is the subject of pre-clinical discovery collaboration.